Burt barely rescues newcomer (and owner of the local tour business) Tyler Reed from El Blanco, and the trouble isn't over yet. El Blanco is becoming more aggressive by the day and the residents of Perfection have to figure out why before they become the next meal.
Three people are found dead in an abandoned silver mine, their bodies completely drained of all fluids. Rosalita thinks a ghost is responsible, but Burt knows it must be something else, especially when two government agents have just rolled into Perfection
Burt tracks down and kills a Shrieker out in the valley, only to find out it was part of a government funded project to train Shriekers for rescue missions. But when a storm knocks damages the equipment controlling them, the remaining Shriekers escape and begin to multiply. In an effort to survive the Perfection residents must make a stand at Burt's place.
An Ass-Blaster is sighted in the valley, already having killed two people. After attempting to track it down, Burt and Tyler learn to their frustration that the Ass-Blaster is private property and must be taken in alive... Which of course, is easier said than done. Meanwhile, Jodi and the others take over teaching Burt's survival class with suprising results.
A team of scientists find an animal/plant hybrid growing in the valley that proves to be just as deadly as it is strange. Burt, Tyler, and Cletus join forces with them to figure out how to destroy it before it spreads out of the valley.
Two criminals named Max and Frank have arrived in town fresh from Las Vegas. With time kil, they decide to take Tyler's tour to settle an arguement about the existence of Graboids. They soon encounter El Blanco, which promptly eats Max and also eats the key needed to complete their next crooked job. Now El Blanco is in danger as Frank returns with his boss to retrieve the key by force.
Twitchell sends Burt and Tyler to a small town track down a suspected Graboid after a bunch of strange disappearances. But the townspeople believe the real cause is alien abductions and that the government is trying to cover it up.
The Perfection residents meet a strange old man claiming to be a scientist called Cletus. At first his ramblings of a dangerous monster on the loose are shrugged off as nothing but El Blanco sightings until the residents finally see it for themselves. Now Burt and Tyler team up with Cletus to try and stop the beast.
Protesters come to Perfection to force Burt and the others out of the valley, claiming their presence is having adverse effects on El Blanco's health. This couldn't have happened at a worse time as El Blanco begins acting very strangely.
A plague of strange bugs infest the valley. They start eating dry wood, but they soon move onto meat and start heading toward the town.
Frank returns to Perfection with some extra help in another attempt to kill El Blanco and retrieve the key he swallowed. Meanwhile, Larry encounters a creature in a barn and tries to figure out what it is.
With the entire town struggling financially Rosalita decides to take a job at Melvin's latest business venture, the Oasis. But some of the water used in the Oasis' lagoon is contaminated with Mixmaster, which creates a deadly six foot shrimp. Now Tyler and the others must stop it before it escapes into the wild.
Shriekers are spotted in Juniper, Arizona, and Twitchell sends Burt and Tyler to take care of it. However, the Fish and Wildlife Service are also in town and after a failed attempt to kill and contain the Shriekers they have multiplied and are out of control. Now Burt and Tyler have to stop them before they massacre the entire town.