Yancy Derringer returns to his hometown of New Orleans after the Civil War and encounters a trio of dishonest gamblers, and old galpal, and the civil administrator of New Orleans.
Colton asks Yancy to help clean up the notorious Gallatin Street area of New Orleans which is under the control of the dishonest Toby Cook.
Colton assigns Yancy to take a large sum of money up the river to Natchez aboard a riverboat. Yancy must figure out a way to protect the loot from robbers.
A woman hires a professional gambler to provoke a duel with John Colton and kill him. Yancy then comes to the aid of his friend.
An Irish damsel is convinced that Yancy is her Mr. Right after he saves her life.
Colton's visiting sister is targeted by a revenge seeking gang.
Yancy investigates when the secretary of a general is killed before he can deliver an important message to Colton.
A crude but wealthy man asks Yancy to help find him a wife.
Even though a presidential pardon has arrived to save a man from a firing squad, a vengeful Army officer tries to see that the execution proceeds.
New Orleans shopkeepers are getting offers they can't refuse to sell their stores.
Yancy goes undercover to discover who's behind a series of robberies against New Orleans merchants.
A dog named Dixie might hold a clue to where Yancy's father buried some treasure.
Yancy and Pahoo are blamed for a local crime wave and find themselves arrested and sentenced to death.
A crazy little old man steals some dynamite and threatens to blow up the levee that holds back the waters from New Orleans.
Yancy is on the scene when a band of Mississippi River pirates nearly set off an international incident.
Yancy helps a flower vendor in her struggle against a protection racket.
Yancy must protect a visiting Russian duke with an eye for hot women and a taste for fine vodka.
Madame Francine wins a lottery but doesn't live long enough to collect her winnings.
Colton assigns Yancy to investigate when a series of women in and around New Orleans are assaulted by someone dressed as a clown.
A woman devises a plan to save her estate from being overrun by flooding but it could lead to New Orleans being devastated by floodwaters.
During a visit to Virginia City, Yancy sits in on a poker game and wins half interest in silver mine.
Visiting Civil War hero and Indian fighter George Custer arrives in New Orleans only to find himself being stalked by a vengeful Native American.
Colton sends Yancy to investigate a series of riverboat accidents that have occurred near New Orleans.
Yancy is accused of being the man who sold John Wilkes Booth the gun he used to assassinate Abraham Lincoln.
A widow who's trying to help the orphans of New Orleans involves Yancy in some questionable activities.
Yancy and Pahoo try to prevent a potentially bloody Native American uprising by the Pawnee tribe.
Yancy gets challenged to a duel and almost winds up at the wrong end of a hangman's rope.
Yancy's investigation of gunrunning on the Mississippi River gets sidetracked by a river queen and a boxer.
A former Civil War general comes charging into New Orleans to break up a counterfeiting ring.
Yancy rides to Missouri to save a friend who's scheduled to hang for a crime committed by the infamous James Gang.
New Orleans is plagued by a series of mysterious incidents which appear to be the work of voodoo.
A suspicious firecracker turns out to contain opium.
Yancy travels to Virginia City once again to check up on the status of his silver mine and sees a tombstone in a cemetary with his name on it.
Yancy is traveling to Promontoary, Utah in order to attend the Golden Spike Ceremony linking two railroads together when he overhears a plot to sabotage things.