Peyton Manning and the Colts (14-2 last season) come to the Meadowlands to play little brother Eli Manning and the Giants (11-5 last season) on the Sunday opener.
The Dallas Cowboys (4-3) travel to the Carolina Panther's (4-4) home turf, hoping that naming a new head quarterback will help defeat Jake Delhomme and his team of Panthers.
Peyton Manning and the Indianapolis Colts (8-0) hope to keep their perfect record intact when they travel to Foxborough, Massachusetts to play the Patriots (6-2).
Philadelphia and Dallas share a Christmas meeting where Terrell Owens hopes that he and the Cowboys can defeat Jeff Garcia and other Eagles in Irving, Texas.