Donovan McNabb continues his return from last years season ending injury as his Philadelphia Eagles venture into Pittsburgh to play the Steelers, led by Ben Roethlisberger.
Dallas (2-0) at Chicago (1-1). Tony Romo leads the high-scoring Cowboys against the typically strong Bears defense anchored by Brian Urlacher. This is the teams' first Soldier Field meeting since 1998.
Looking to rebound from their first loss of the season, Peyton Manning and the Colts (7-1) travel to San Diego to play LaDainian Tomlinson and the Chargers (4-4).
QB Tom Brady and his prime WR Randy Moss will lead New England Patriots (9-0) into Ralph Wilson Stadium in Buffalo to face the Bills (5-4) and their 4 game win streak.
QB Todd Collins will make his first start in ten seasons as he leads the Washington Redskins (6-7) into the Meadowlands Stadium to face defensive sack master Michael Strahan and the NY Giants (9-4).
Washington Redskins (7-7) and the Minnesota Vikings (8-6) will both try and hold on to their slim playoff hopes tonight in a battle from the Hubert H Humphrey Metrodome.