The Patriots and Giants also played in Week 17 of the regular season, with New England winning 38-35, completing their 16-0 record.
The Patriots were the favorite by 12.
Jordin Sparks, the previous American Idol winner, sang the National Anthem.
The Patriots defeated the San Diego Chargers 21-12 to get to the Super Bowl, while the Giants defeated the Green Bay Packers 23-20 in overtime to get there.
The Patriots were 18-0 entering this game, trying to become only the second team to go undefeated in the entire season.
Eli Manning won the Super Bowl MVP award a year after his brother Peyton won the award.
The second most watched television program ever in the United States. The Nielsen Rating was 43.3.