"Tumhari Disha" is a family drama serial revolving around Disha and the moments that change her life forever. Vijeyendra and Suhasini Bhosle have raised their two daughters Disha and Rano as equals - well almost equals. However a dark secret from the past threatens to create a rift between the 2 sisters. When Suhasini realizes that Rano is in love with Inder, however Inder is keener to marry Disha, Suhasini lets the cat out of the bag. She discloses the fact to Disha that she is not their biological child but their servant's child.
Mr. Dushyant Sehgal aka DK, a powerful diamond tycoon proposes Disha to pose nude for his Jewellery Ad. Disha refuses to accept the proposal.
However destiny has something else in store for Disha. Disha's father Mr Bhosle meets with an accident and dies. Disha is left with no choice but to accept Dk's proposal, however she accepts the same on he condition that Dk marry her.
The relationship, which had started on a sour note, takes a turn when Dk realizes that he loves Disha. Jealousy and Possessiveness adds spice to the growing relationship between Disha and Dk. Gargi, Dk's step mother is a cunning and shrewd lady who wants to grab hold of Dk's empire all to herself.
Disha and dk manage to survive through all the odds. They make it big in life again only when life has something else in store for them. Dk meets with an accident, which leaves him paralytic waist down. Dk is so devastated that he wants Disha to move on in her life. Dk in his own way encourages disha to marry his friend however Disha chooses to be Dk's for all her life. Disha ends her life before she is forced to marry Dk's friend. Before dying Disha makes dk promise to get on with life.
Dk moves on as promised. He marries a simpleton Kamna and has three children Dhan, Veer and Dhruvi. Dk has pampered his children and has completely ignored his wife kamna. Dk still lives with the memories of his ex-wife Disha. Dk agrees to his son getting married to Surily, who is a very shrewd and cunning person. Dk starts receiving threats to stop the wedding. Dk keeps ignoring the same. The day of the wedding arrives. Dk gets kidnapped before the wedding..