A former lawman tangles with an old enemy on his wedding day--wagon train scout Cooper Smith.
Coop and Barnaby West go on a buffalo hunt with a group of hide hunters--one of whom enjoys bullying Barnaby.
When wounded outlaw John Gillman stumbles into camp, he's befriended by an orphan girl who has a dark secret.
Bill Hawks and Barnaby West escort two young women to a wide-open tent city of gambling and honky tonks where they think there are jobs as a singers waiting for them.
Bostonian Barbara Lindquist is the only survivor of a bandit attack on a stagecoach. A badly injured Coop tries to lead her to safety.
Brian Conlin forms an almost immediate distrust of wagonmaster Hale when he and his party stumble into camp.
Coop becomes romantically involved with a half-breed girl he found wandering in the wilderness.
Hale has no room in his train for Ben Campbell, an ex-convict whose life has been threatened by a former cohort in crime.
Richard Bloodgood, an old friend of Coop's who's now blind, joins the wagon train with one purpose--to kill his old pal.
The wagon train is faced with all kinds of troubles. Coop is wounded, Bill Hawks is seriously ill, and the Comanches are on the warpath. Then a small detachment of cavalry arrives, which doesn't please Clay Shelby. It seems as though he's a deserter.
A little girl is heard crying in the night but she vanishes and Charlie Wooster is the only one who got a good glimpse of her.
Charlie Wooster, Barnaby West, and Bill Hawks try to help an inventor launch the first "flying machine."
Coop gets himself captured by an outlaw band whose members include two females.
Wanda Snow has a premonition that Coop's life is in danger.
Charlie Wooster and Coop ride into a town to get supplies, only to find the town deserted with it appearing that everyone packed up and left in one big hurry.
Native Americans are in awe of Jamison Hershey's huge Clydesdale horse named Herman.
Tightwad spinster Mary Lee McIntosh considers the fee for joining the wagon train to be way too high so she plans on following the train at a distance in her lone wagon.
A female tugboat skipper receives a surprise when the wagon train brings her two visitors--her sailor son and his new bride.
Coop is recruited to pose as the husband of his old girlfriend's twin sister.
Barnaby kills a masked bandit and is guilt-stricken when it's discovered that the bandit was approximately his own age.
Bill Hawks refuses to turn a Native American girl over to Chief Crazy Bear, who wants revenge on her for the death of his son.
Coop tells Bill Hawks the story of the Earp brothers and a lady who died in the wreck of a stagecoach carrying a shipment of silver.
In this flashback episode, Charlie Wooster recalls his younger days working at a frontier trading outpost for a man named Jarbo Pierce.