With Mutant-hate-crimes beginning to become a real problem in Bayville, Spyke returns more powerful than ever. However, he is not the only one to return, but Duncan Matthews does as well, causing all kinds of trouble for mutants.
The X-men, Brotherhood, and Acolytes only have a short amount of time till Apocalypse completes his master plan. Wolverine, Nightcrawler, and Cyclops find themselves in a battle with Mystique, the mutant that is guarding Apocalypse. Can they get through in time to stop Apocalypse? Meanwhile the other mutants face off against their former allies, can they hold their own while Wolverine's team takes out Apocalypse?