| Name (Sort) | Character (Sort) | |
| •Reeve Carney | played | Dorian Gray (20Eps.) |
| •Timothy Dalton | played | Sir Malcolm Murray (23Eps.) |
| •Eva Green | played | Vanessa Ives (23Eps.) |
| •Rory Kinnear | played | The Creature (22Eps.) |
| •Patti LuPone | played | Dr. Seward (season 3+) (6Eps.) |
| •Billie Piper | played | Brona Croft / Lily (21Eps.) |
| •Wes Studi | played | Kaetenay (season 3+) (6Eps.) |
| •Harry Treadaway | played | Dr. Victor Frankenstein (23Eps.) |
| •Josh Hartnett | played | Ethan Chandler (23Eps.) |
| •Helen McCrory | played | Evelyn Poole / Madame Kali (season 2) (9Eps.) |
| •Simon Russell Beale | played | Ferdinand Lyle (8Eps.) |
| •Danny Sapani | played | Sembene (17Eps.) |