Aliens in the Family is the story of a big-hearted human dad, Doug Brody, who was abducted by a spacecraft, fell in love with an alien single mom, Cookie, and returned to Earth to marry her and raise their unusual brood of human and alien children. Doug's two human kids, nine-year-old Adam and 14-year-old self-obsessed Heather, are alternately delighted and exasperated by their three extraterrestrial siblings—their brother Spit, 14, who was prone to grossing everyone out; bookish sister Snizzy, 10; and baby brother Bobut, acts as if he's Emperor of the Universe, and with good reason —- he is. Rounding out the family is Bobut's nanny, Sally Hagen, who is often the target of his imperious wrath, but who knows how to charm him with chocolate pudding. Sugar Pie was Bobut's toy bunny rabbit.
Spit invents an alien holiday to get out of schoolwork, but Bobut overhears and expects a Tweenax celebration. Meanwhile, Doug makes plans for a family vacation, but Sally has difficulty getting Bobut's passport photo taken when Bobut decides to terrorize the clown photographer.