| Name (Sort) | Character (Sort) | |
| •Mindy Kaling | played | Dr. Mindy Lahiri (1Eps.) |
| •Chris Messina (1) | played | Dr. Danny Castellano (1Eps.) |
| •Ed Weeks | played | Dr. Jeremy Reed (2Eps.) |
| •Ike Barinholtz | played | Morgan Tookers (episodes 13, 15 - present) |
| •Beth Grant | played | Beverley Janoszewski (episodes 15 - present) |
| •Xosha Roquemore | played | Tamra Webb (episodes 25 - present) |
| •Adam Pally | played | Dr. Peter Prentice (episodes 29 - present) |
| •Zoé Jarman | played | Betsy Putch (episodes 1 - 46) (2Eps.) |
| •Anna Camp | played | Gwen Grandy (episodes 1 - 12) (1Eps.) |
| •Amanda Setton | played | Shauna Dicanio (episodes 1 - 12) (1Eps.) |
| •Stephen Tobolowsky | played | Dr. Marc Shulman (episodes 1 - 2, 8) (1Eps.) |