In the aftermath of Kelly and Juliette's deaths, Nick's friends question whether he can handle the strain. Meanwhile, Trubel goes missing and Nick is blaming an FBI agent... and Adalind goes into labor.
With Nick on leave, Hank gets a new partner as he investigates the case of a seemingly mild-mannered accountant who is actually a vicious Wesen killer... with ties to the organization that killed Chavez. Meanwhile, Adalind moves in with Nick because she has nowhere else to go.
Four homeless Wesen children lose the "mother" that they kidnapped and decide to take Rosalee as their new mother. Meanwhile, Nick moves Adalind and Kelly to his new home, and Renard meets with Meisner for the first time since the King's death.
A man trying to kill a mobster is himself killed by a Wesen, and Nick and Hank determine that an old ritual is at the heart of the murder. Meanwhile, a mayoral candidate asks Renard for his support, Rosalee receives a letter from an old friend, and Nick and Adalind continue to adjust to living together.
While Nick and Hank investigate the deaths of two Wesen, Trubel recovers at the hospital. However, the Occultatum Libera have tracked her down and have their own plans. Meanwhile, Meisner contacts Adalind.
A local gang of Wesen attack Wesen shop owners, and Nick and Hank soon discover that the attacks are deliberate... and tied to the Uprising. Meanwhile, Trubel settles in at the fortress, and Renard films an ad for the mayoral candidate.
Not everything is as it seems regarding Juliette's return. Monroe and Rosalee want some answers about increased Wesen violence.
Meisner reunites Nick and Eve after the assassination at the restaurant. Meanwhile, Nick and Hank investigate a mysterious death at Diamond Lake, and Rosalee receives another letter from someone in her past life.
A barbaric Wesen ritual is brought to the present and Nick, Hank, and Wu are already five steps behind the serial killer. To aid in the investigation, Monroe goes undercover. Meanwhile, Hadrian's Wall's war against Black Claw intensifies as Eve uses her unique skills to interrogate a suspect.