While Nick and the others deal with the FBI questioning Trubel over her role in Weston's decapitation, a new Wesen strikes in Portland, draining the memories from his victims.
While Nick and Hank continue their investigation of the memory-stealing Wesen with Trubel's help, Viktor imprisons Adalind before she discovers that he doesn't have her baby. Meanwhile, a mysterious woman from Renard's past saves the captain's life.
Nick and Hank find themselves in over their heads when they investigate a Wesen-related murder. Without Nick's abilities, they have to rely on Trubel to locate the Wesen. Meanwhile, Wu continues to ask questions and Adalind turns to a fellow prisoner for help escaping.
A bizarre murder involves pouring clay into the victim's body. Both Nick and the dead man's brother suspect that the victim's family was responsible. Meanwhile, Rosalee and Monroe work with Elizabeth to reverse Adalind's spell, while in Vienna Adalind tries to escape Viktor's castle.
Nick and Hank investigate a woman driven to the brink of madness by what appears to be hallucinations of a talking humanoid wolf. Meanwhile, Elizabeth tells Nick and Juliette how to restore Nick's powers, and Adalind tries to find her daughter in Viktor's castle.
While Nick waits to see if Elizabeth's cure restores his powers, he and Hank investigate a car crash where one of the passengers disappeared... apparently abducted by Wesen. Meanwhile, Elizabeth says her farewells to Renard, while Adalind and Viktor compare notes and realize that Kelly has Diana.
Nick and Hank investigate a series of Christmas break-ins that turn out to be caused by childlike goblins. Meanwhile, Trubel and Josh track down the Wesenrein, Juliette suffers from nausea, and Monroe invites Rosalee on a belated honeymoon.
The legendary Chupacabra kills a man in a quiet suburban street, and Nick and Hank soon realize a Wesen is responsible. However, when Wu sees the Chupacabra, the detectives have to deal with his knowledge of the Wesen. Meanwhile, Adalind and Viktor realize that Kelly and Adalind's baby are tied to Portland, while the Resistance orders Renard to help them find the baby as well.
The Wesenrein abduct Monroe, and Nick and Hank realize that there is a mole in the Portland police department. Meanwhile, Wu learns the truth about the Wesen, while Juliette discovers that she is changing into something different.
Monroe's life hangs in the balance as the team turns to Bud and Wu for help to track down the Wesenrein and stop the racist organization before they can execute their friend. Meanwhile, Juliette continues to transform.
With Monroe and Rosalee on their honeymoon, Nick, Hank, and Wu aer on their own when they investigate a shocking murder at a supposedly haunted house. Meanwhile, Renard contacts a mysterious woman from his past to help Juliette deal with her new condition.
Nick and Hank investigate a series of murders that lead back to the Wesen Council and a mysterious bounty hunter. Elsewhere, Juliette's meeting with Henrietta brings about more disturbing news than she was expecting. Meanwhile, Adalind and Viktor make their way back to Portland.