In the aftermath of Kelly and Juliette's deaths, Nick's friends question whether he can handle the strain. Meanwhile, Trubel goes missing and Nick is blaming an FBI agent... and Adalind goes into labor.
With Nick on leave, Hank gets a new partner as he investigates the case of a seemingly mild-mannered accountant who is actually a vicious Wesen killer... with ties to the organization that killed Chavez. Meanwhile, Adalind moves in with Nick because she has nowhere else to go.
Four homeless Wesen children lose the "mother" that they kidnapped and decide to take Rosalee as their new mother. Meanwhile, Nick moves Adalind and Kelly to his new home, and Renard meets with Meisner for the first time since the King's death.
A man trying to kill a mobster is himself killed by a Wesen, and Nick and Hank determine that an old ritual is at the heart of the murder. Meanwhile, a mayoral candidate asks Renard for his support, Rosalee receives a letter from an old friend, and Nick and Adalind continue to adjust to living together.
While Nick and Hank investigate the deaths of two Wesen, Trubel recovers at the hospital. However, the Occultatum Libera have tracked her down and have their own plans. Meanwhile, Meisner contacts Adalind.
A local gang of Wesen attack Wesen shop owners, and Nick and Hank soon discover that the attacks are deliberate... and tied to the Uprising. Meanwhile, Trubel settles in at the fortress, and Renard films an ad for the mayoral candidate.
Not everything is as it seems regarding Juliette's return. Monroe and Rosalee want some answers about increased Wesen violence.
Meisner reunites Nick and Eve after the assassination at the restaurant. Meanwhile, Nick and Hank investigate a mysterious death at Diamond Lake, and Rosalee receives another letter from someone in her past life.
A Wesen commits two ritual murders, and the lore reveals that five more must be committed to complete the ceremony. Meanwhile, a Black Claw recruiter arrives in Portland, and HW interrogates a captured suspect.
Monroe's uncle stumbles across a rare find: a collection of ancient Grimm books. While the team try to obtain them before Black Claw does, Renard offers the election team his knowledge of their opponent's criminal background.
Nick and Adalind draw closer before Nick leaves for Germany to track down the Templar treasure. Meanwhile, the Black Claw assassin closes in on his target.
Nick and Monroe follow the clues to the Grimm crusades' treasure, but the locals in Germany pursue them. Meanwhile, both Renard and HW try to track Marwan, but end up crossing paths.
An aspiring Luchador goes to a maskmaker to obtain a mask that will make him invincible, and is forced to sign in blood to obtain what he wants. Meanwhile, Rachel contacts Renard again, while Eve investigates Andrew's assassination.
A real estate agent goes off the road and claims that he was attacked afterward. However, Nick and Hank suspect something is up and soon discover that the agent's family is afflicted with a rare Wesen genetic disorder. Meanwhile, Renard meets with Adalind to discuss their daughter, and Eve searches Rachel's home.
When Nick and Hank come across a beautiful young woman who seems to have aged 70 years overnight and died, they suspect Wesen involvement. The investigation leads to a local doctor and Rosalee is enlisted to help find the truth. Meanwhile, Eve takes bold steps to learn more about Capt. Renard's nefarious dealings.
When the severed head of a young man is found under a bridge, Nick and Hank find themselves on the case of Japanese Wesen acting on an ancient tradition of revenge. Elsewhere, Adalind decides to go back to work at her old law firm and has her first face-to-face with Eve.
When a man is found dead with all of the bones in his body seemingly liquefied and removed, Nick and Hank find themselves in the middle of a gruesome family arrangement. Meanwhile, Wu deals with a crisis of his own and Hank reunites with his old flame, Zuri.