| Name (Sort) | Character (Sort) | |
| •Kerry Washington | played | Olivia Pope (69Eps.) |
| •Scott Foley | played | Jake Ballard (S03+; Recurring S02) (42Eps.) |
| •Darby Stanchfield | played | Abby Whelan (69Eps.) |
| •Katie Lowes | played | Quinn Perkins / Lindsay Dwyer (67Eps.) |
| •Guillermo Diaz | played | Huck (68Eps.) |
| •Jeff Perry | played | Cyrus Beene (68Eps.) |
| •Joshua Malina | played | David Rosen (S02+; Recurring S01) (56Eps.) |
| •Bellamy Young | played | First Lady Mellie Grant (S02+; Recurring S01) (59Eps.) |
| •Tony Goldwyn | played | President Fitzgerald "Fitz" Grant (66Eps.) |
| •Columbus Short | played | Harrison Wright (Seasons 1-3) (46Eps.) |
| •Henry Ian Cusick | played | Stephen Finch (Season 1) (7Eps.) |
| •Portia de Rossi | played | Elizabeth North (S05+ (recurring S04)) |