| Name (Sort) | Character (Sort) | |
| •Nina Dobrev | played | Elena Gilbert (133Eps.) |
| •Paul Wesley | played | Stefan Salvatore (133Eps.) |
| •Ian Somerhalder | played | Damon Salvatore (133Eps.) |
| •Steven R. McQueen | played | Jeremy Gilbert (97Eps.) |
| •Kat Graham | played | Bonnie Bennett (102Eps.) |
| •Zach Roerig | played | Matt Donovan (99Eps.) |
| •Candice Accola | played | Caroline Forbes (114Eps.) |
| •Michael Trevino | played | Tyler Lockwood (81Eps.) |
| •Matthew Davis | played | Alaric Saltzman (episode 14- (recurring previously)) (56Eps.) |
| •Joseph Morgan | played | Klaus (Season 3 - present (recurring previously)) (37Eps.) |
| •Kayla Ewell | played | Vicki Donovan (episodes 1-7) (7Eps.) |
| •Michael Malarkey | played | Enzo (S6-) (17Eps.) |
| •Sara Canning | played | Jenna Sommers (Seasons 1 & 2) (31Eps.) |